Solvent Effects on Chiral Resolution via Chromatography Across 158 Reactions

Abstract

Recent advances in transformer-based approaches have opened new routes to studying chiral resolution via chromatography. Using equipment available in most teaching laboratories, we replicate and extend prior findings across 3234 experimental runs. Results show a 3% gain in accuracy alongside a marked reduction in variance between replicates. These findings suggest a practical path toward broader adoption via citizen-science data.