Solvent Effects on Photoredox Reaction Optimization Across 473 Reactions

Abstract

Despite sustained attention from the research community, photoredox reaction optimization remains difficult to study outside well-funded laboratories. Using equipment available in most teaching laboratories, we replicate and extend prior findings across 2349 experimental runs. We observe a statistically significant effect (p < 0.01) that persists across all tested conditions. We release our data and code to support replication by other student researchers.